Unstable coronary syndromes, i.e. unstable or severe angina; recent MI (within 1 month)

CHF: severe (class IV), new, or worsening

Significant arrhythmia: high grade AVB, Mobitz II AVB, 3rd deg AVB, symptomatic ventricular arrhythmia, supraventricular arrhythmia including a-fib with uncontrolled ventricular rate (>100), symptomatic bradycardia, new V-tach

Severe valve disease, i.e. severe AS, symptomatic MS